N-acetylcysteine Reverses Diastolic Dysfunction and Hypertrophy in Familial 36 Hypertrophic Cardiomyopathy
نویسندگان
چکیده
R. John Solaro, PhD 20 Department of Physiology and Biophysics (M/C 901) 21 College of Medicine 22 835 S. Wolcott Ave 23 University of Illinois at Chicago 24 Chicago, IL 60612 25 Tel.: 312-996-7620; Fax: 312-996-1414 26 E-mail: [email protected] 27 28 29 30
منابع مشابه
N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy.
S-glutathionylation of cardiac myosin-binding protein C (cMyBP-C) induces Ca(2+) sensitization and a slowing of cross-bridge kinetics as a result of increased oxidative signaling. Although there is evidence for a role of oxidative stress in disorders associated with hypertrophic cardiomyopathy (HCM), this mechanism is not well understood. We investigated whether oxidative myofilament modificati...
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